Conceived as computational hardware, the scale of the universe sheds awesomeness fast:
The entire visible universe since the big bang is capable of having performed 10^122 operations and of storing 10^92 bits. While these are large numbers, they are still quite finite. 10^122 is roughly 2^406, so the entire universe used as a massive quantum computer is still not capable of searching through all combinations of 500 bits.
This limitation is good news for our ability to design infrastructure today that will still constrain future superintelligences. Cryptographic systems that require brute force searching for a 500 bit key will remain secure even in the face of the most powerful superintelligence. In Base64, the following key:
would stymie the entire universe doing a brute force search.